49ers vs. Rams odds, prediction, betting trends for NFL’s ‘Sunday Night Football’ game – Sporting News


When the Rams (4-1) travel north to San Francisco to take on the 49ers (2-3) on “Sunday Night Football” in Week 6 (8:20 p.m. ET, NBC), it’s a tale of two recent NFC champions from the NFC West going in different directions. While the Rams try to gain ground on the idle first-place Seahawks (5-0), the 49ers are just looking to get back to .500 and sneak back into the wild-card race.

The Rams, with elite inside pass rusher Aaron Donald and shutdown cornerback Jalen Ramsey, are playing strong defense. They have also rediscovered their mighty rushing attack for Sean McVay to better support Jared Goff’s passing.

The 49ers’ defense has been riddled with major injuries, none bigger than pass rusher Nick Bosa. Offensively, they are just getting back to full health in the passing game with Jimmy Garoppolo, George Kittle, Deebo Samuel and Brandon Aiyuk to try to help red-hot running back Raheem Mostert, who also had to miss time with a knee injury.

Here’s everything to know about betting on 49ers vs. Rams in Week 6, including updated odds, trends and our prediction for “Sunday Night Football.”

WEEK 6 NFL PICKS: Against the spread | Straight up

Betting odds for “Sunday Night Football”

  • Spread: Rams by 3.5
  • Over/under: 51.5
  • Point spread odds: Rams +105, 49ers -125

The Rams have been a little better than field-goal favorites down the road in California all week. They are the healthier team playing better overall football at the moment and the 49ers have